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Tagu Denis

Tagu Denis
Team: Ecology and Genetics of Insects

Phone: (+33) 2 23 48 51 65
Denis.Tagu@inra.fr
Senior Scientist, INRA

UMR 1349 IGEPP, BP 35327 - 35653 Le Rheu Cedex - France

Tel: (+33) 2 23 48 51 65

Tel: (+33) 6 76 35 67 93

e-mail: denis.tagu@inra.fr

Education and Professional Experience

  • INRA Senior Scientist position, Insect genomics and phenotypic plasticity, Rennes, France (2002-today)
  • Sabbatical, CRG (Barcelona, Spain), August 2017-January 2018
  • INRA Junior Scientist position, Plant-Fungal symbiotic interactions, Nancy, France (1991-2002)
  • Post-doc fellowship (European Union), Plant Molecular Genetics, CSIC, Barcelona, Spain (1989-1991)
  • PhD Plant Molecular Physiology, Orsay-Paris University, France (1985-1988)

Management

  • International Aphid Genomics Consortium (www.aphidbase.com)
  • Associate Editor Insect Science
  • Member of the i5K coordinating group (http://arthropodgenomes.org/wiki/i5K)
  • Member of the GIGA consortium (http://giga-cos.org/)
  • Coordination of 4 insect genome sequencing (http://www.spe.inra.fr/Toutes-les-actualites/i5k-sequencer-5000-genomes-d-insectes)
  • Coordination of ANR project on association genetics in the pea aphid (2012-2014)
  • Coordination of ANR project on microRNAs and gene network in the pea aphid (2009-2012)
  • Coordination of ANR project on genes responsible for sex determination in aphids (2018-2020)
  • Partner of the European Training Network IGNITE on invertebrate genomics (2018-2022)
  • Head of the Institute of Genetics, Environment and Plant Protection: more than 260 persons involved in describing, understanding and modeling agroecosystems, plants and their pathogens, pests and auxiliaries (2012-2016)
  • Associate Editor BMC Genomics
  • Associate Editor Current Opinion Insect Science

Areas of Focus

  • Genomics
  • Integrative genomics
  • Bioinformatics
  • Insect adaptation
  • Phenotypic plasticity

Selected publications (July 2017 - h index: 31 – citations: 2848)

Genome and genome-derived papers

The International Aphid Genomics Consortium, Tagu D., Legeai F., Gauthier J.P., Rispe C., Ollivier M. & Jaubert-Possamai S. (2010). Genome sequence of the pea aphid Acyrthosiphon pisum. PLoS Biology 8(2):e1000313. DOI

Rispe C, Kutsukake M, Doublet V, Hudaverdian S, Legeai F, Simon JC, Tagu D, Fukatsu T (2008) Large gene family expansion and variable selective pressures for cathepsin B in aphids. Molecular Biology and Evolution 25:5-17. DOI

Jaubert-Possamai S., Rispe C., Tanguy S., Gordon K., Walsh T., Edwards O. & Tagu D. (2010). Expansion of the miRNA pathway in the hemipteran insect Acyrthosiphon pisum. Molecular Biology and Evolution 27(5):979-987. DOI

Walsh T.K., Brisson J.A., Robertson H.M., Gordon K., Jaubert-Possamai S., Tagu D. & Edwards O.R. (2010). A functional DNA methylation system in the pea aphid, Acyrthosiphon pisum. Insect Molecular Biology 19(s2):215-228. DOI

Carolan J.C., Caragea D., Reardon K.T., Mutti N.S., Dittmer N., Pappan K., Cui F., Castaneto M., Poulain J., Dossat C., Tagu D., Reese J.C., Reeck G.R., Wilkinson T.L. & Edwards O.R. (2011). Predicted Effector Molecules in the Salivary Secretome of the Pea Aphid (Acyrthosiphon pisum): A Dual Transcriptomic/Proteomic Approach. Journal of Proteome Research 10(4):1505-1518. DOI

Lu H.-l., Tanguy S., Rispe C., Gauthier J.-P., Walsh T., Gordon K., Edwards O., Tagu D., Chang C.-c. & Jaubert-Possamai S. (2011). Expansion of Genes Encoding piRNA-Associated Argonaute Proteins in the Pea Aphid: Diversification of Expression Profiles in Different Plastic Morphs. PLoS ONE 6(12):e28051. DOI

Ollivier M., Gabaldón T., Poulain J., Gavory F., Leterme N., Gauthier J.-P., Legeai F., Tagu D., Simon J.C. & Rispe C. (2012). Comparison of gene repertoires and patterns of evolutionary rates in eight aphid species that differ by reproductive mode. Genome Biology and Evolution 19(2):33-45. DOI

Ortiz-Rivas B, Jaubert-Possamai1 S, Tanguy S, Gauthier JP, Tagu D, Rispe C. (2012) Evolutionary study of duplications of the miRNA machinery in aphids associated with striking rate acceleration and changes in expression profiles. BMC Evolutionary Biology, 12:216. DOI

i5k consortium (Hackett et al. dont Tagu D). The i5K Initiative: Advancing Arthropod Genomics for Knowledge, Human Health, Agriculture, and the Environment (2013). Journal of Heredity 104 595-600. DOI

Tagu D., Colbourne J.K., & Nègre N. (2014). Genomic data integration for ecological and evolutionary traits in non-model organisms. BMC genomics 15: 490. DOI

Rispe C, Legeai F, Papura D, Bretaudeau A, Hudaverdian S, Le Trionnaire G, Tagu D, Jaquiéry J & Delmotte F (2016) De novo assembly of the grapevine phylloxera transcriptome allows identification of genes differentially expressed between leaf- and root-feeding forms. BMC Genomics 17: 219. DOI

Mathers TC, et al., including Tagu D. (2017) Rapid transcriptional plasticity of duplicated gene clusters enables a clonally reproducing aphid to colonise diverse plant species. Genome Biology 18, 27. DOI

Phenotypic plasticity

Le Trionnaire G, Jaubert S, Sabater-Muñoz B, Benedetto A, Bonhomme J, Prunier-Leterme N, Martinez-Torres D, Simon JC, Tagu D (2007) Seasonal photoperiodism regulates the expression of cuticular and signalling protein genes in the pea aphid. Insect Biochemistry and Molecular Biology 37 1094-1102. DOI

Rispe C, Legeai F, Gauthier JP, Tagu D (2007) Strong heterogeneity in nucleotidic composition and codon bias in the pea aphid (Acyrthosiphon pisum) shown by EST-Based coding genome reconstruction. Journal of Molecular Evolution 65:413-424. DOI

Le Trionnaire G, Francis F, Jaubert S, Bonhomme J, De Pauw E, Gauthier JP, Haubruge E, Legeai F, Prunier-Leterme N, Simon JC, Tanguy S, Tagu D (2009) Transcriptomic and proteomic analyses of seasonal photoperiodism in the pea aphid. BMC Genomics, 10(456):14. DOI

Huybrechts H, Bonhomme J, Minoli S, Prunier-Leterme N, Dombrovsky A, Abdel-Latief M, Robichon A, Veenstra JA, Tagu D (2010) Neuropeptide and neurohormone precursors in the pea aphid Acyrthosiphon pisum. Insect Molecular Biology, 19(s2):87-95. DOI

Legeai F., Risk G., Walsh T., Edwards O., Gordon K., Lavenier D., Leterme N., Méreau A., Nicolas J., Tagu D. & Jaubert-Possamai S. (2010). Bioinformatic prediction, deep sequencing of microRNAs and their role in phenotypic plasticity in the pea aphid, Acyrthosiphon pisum. BMC Genomics 11:281. DOI

Gallot A., Shigenobu S., Hashiyama T., Jaubert-Possamai S. & Tagu D. (2012). Sexual and asexual oogenesis require the expression of unique and shared sets of genes in the insect Acyrthosiphon pisum. Bmc genomics 13(1):76. DOI

Ishikawa A., Ogawa K., Gotoh H., Walsh T.K., Tagu D., Brisson J.A., Rispe C., Jaubert-Possamai S., Kanbe T., Tsubota T., Shiotsuki T. & Miura T. (2012). Juvenile hormone titre and related gene expression during the change of reproductive modes in the pea aphid. Insect Molecular Biology 21(1):49-60. DOI

Le Trionnaire G.,  Jaubert-Possamai S., Bonhomme J., Gauthier J.P., Guernec G., Le Cam A., Montfort J. Legeai F., Tagu D. (2012). Transcriptomic profiling of the reproductive mode switch in the pea aphid Acyrthosiphon pisum in response to natural autumnal photoperiod. Journal of Insect Physiology, 58 1517-1524. DOI

Jaquiéry J, Rispe C, Roze D, Legeai F, Le Trionnaire G, Stoeckel S, Mieuzet L, Da Silva C, Poulain J, Prunier-Leterme N, Ségurens B, Tagu D & Simon JC. (2013). Masculinization of the X chromosome in the pea aphid. PLoS Genetics vol 9 e1003690. DOI

Jaquiéry J., Stoeckel S., Larose C., Nouhaud P., Rispe C., Mieuzet L., Bonhomme J., Mahéo F., Legeai F., Gauthier J.P., Prunier-Leterme N., Tagu D. & Simon J.C. (2014). Genetic Control of Contagious Asexuality in the Pea Aphid. PLoS Genetics, 10(12): e1004838. DOI

Richard G, Legeai F, Prunier-Leterme N, Bretaudeau A, Tagu D, Jaquiery Julie, Le Trionnaire G. (2017) Dosage compensation and sex-specific epigenetic landscape of the X chromosome in the pea aphid. Epigenetics and Chromatin, 10, 30. DOI

Tools and resources

Sabater-Muñoz B, Legeai F, Rispe C, Bonhomme J, Dearden P, Dossat C, Duclert A, Gauthier JP, Ducray DG, Hunter W, Dang P, Kambhampati S, Martinez-Torres D, Cortes T, Moya A, Nakabachi A, Philippe C, Prunier-Leterme N, Rahbe Y, Simon JC, Stern DL, Wincker P, Tagu D (2006) Large-scale gene discovery in the pea aphid Acyrthosiphonpisum (Hemiptera). Genome Biology 7. DOI

Jaubert-Possamai S, Le Trionnaire G, Bonhomme J, Christophides GK, Rispe C, Tagu D (2007) Gene knockdown by RNAi in the pea aphid Acyrthosiphon pisum. BMC Biotechnology 7. DOI

Legeai F., Shigenobu S., Gauthier J.P., Colbourne J., Rispe C., Collin O., Richards S., Wilson A.C.C., Murphy T. & Tagu D. (2010). AphidBase: a centralized bioinformatic resource for annotation of the pea aphid genome. Insect Molecular Biology 19(s2):5-12. DOI

Tagu D., Le Trionnaire G., Tanguy S., Gauthier J.P. & Huynh J.R. (2014). EMS Mutagenesis in the Pea Aphid Acyrthosiphon pisum. G3: Genes|Genomes|Genetics, 4: 657-667. DOI

Wucher V., Tagu D., Nicolas J. (2015). Edge Selection in a Noisy Graph by Concept Analysis: Application to a Genomic Network ; Studies in Classification, Data Analysis, and Knowledge Organization In Springer. In press

Reviews and book chapters

Le Trionnaire G, Hardie J, Jaubert-Possamai S, Simon JC, Tagu D (2008) Shifting from clonal to sexual reproduction in aphids: physiological and developmental aspects. Biology of the Cell 100:441-451. DOI

Tagu D, Klingler JP, Moya A, Simon JC (2008) Early progress in aphid genomics and consequences for plant-aphid interactions studies. Molecular Plant-Microbe Interactions 21:701-708. DOI

Gallot-Le Grand A., Rispe C., Leterme N., Gauthier J.P., Jaubert-Possamai S. & Tagu D. (2010). Cuticular proteins and seasonal photoperiodism in aphid. Insect Biochemistry and Molecular Biology 40(3):235-240. DOI

Simon J.C., Stoeckel S. & Tagu D. (2010). Evolutionary and functional insights into reproductive strategies of aphids. Comptes Rendus Biologies 333(6-7):488-496. DOI

Tagu D., Dugravot S., Outreman Y., Rispe C., Simon J.C. & Colella S. (2010). The anatomy of an aphid genome: from sequence to biology. Comptes Rendus Biologies 333(6-7):464-473. DOI

Simon J.C., Pfrender M.E., Tollrian R., Tagu D. & Colbourne J.K. (2011). Genomics of Environmentally Induced Phenotypes in 2 Extremely Plastic Arthropods. Journal of Heredity 102(5):512-525. DOI

Le Trionnaire G, Wucher V, Tagu D (2013) Genome expression control during the photoperiodic response of aphids. Physiological Entomology (2013) 38, 117–125. DOI

Tagu D., Colbourne J.K., &Nègre N. (2014). Genomic data integration for ecological and evolutionary traits in non-model organisms. BMC genomics 15: 490. DOI

Editorial : Coste F. & Tagu D. (2012). 13e journées ouvertes en biologie, informatique et mathématiques. JOBIM 2012 (Rennes, France).

Editorial : Brisson J.A. & Tagu D. (2014). Editorial overview: Insect genomics. Current Opinion in Insect Science, 1: v-vi.

Editorial : Brown S.J. & Tagu D. (2015). Editorial overview: Insect genomics: How to sequence five thousand insect genomes? Current Opinion in Insect Science, 7: iv-v.

Grantham M., Brisson J.A., Tagu D. & Le Trionnaire G. (Accepted) Integrative Genomic Approaches to Studying Epigenetic Mechanisms of Phenotypic Plasticity in the Aphid. In C. Raman, M. R. Goldsmith & T. Agunbiade (Eds.), Short Views on Insect Genomics and Proteomics - Insect Genomics: Springer. Book Series: Entomology in Focus Volume: 3 Pages: 95-117. DOI

Brisson J.A., Jaquiéry J., Legeai F., Le Trionnaire G. & Tagu D. (2017). Genomics of phenotypic plasticity in aphids. In H. Czosnek & M. Ghanim (Eds.), Management of insect pests to agriculture: lessons learned from deciphering their genome, transcriptome and proteome: Springer 65-96. DOI

Tagu D., Calevro F., Colella S., Gabaldon T. & Sugio A. (Accepted). Functional and evolutionary genomics in aphids. In A. Vilcinskas (Ed.), Biology & Ecology of Aphids: CRC Press 52-88.

Loxdale H.D., Edwards D., Tagu D. & Vorburger C. Population Genetic Issues: New Insights Using Conventional Molecular Markers and Genomics Tools. In H. F. van Emden & R. Harrington (Eds.), Aphids as Crop Pests: CABI Press. In press

Books (Editor) (in french)

Tagu D, Moussard C (2003) Principes des techniques de biologie moléculaire. 2nde edition. INRA Editions 176 pages

Book translated in English (2006), Spanish (2006) anf Chinese (2007)

Tagu D. & Risler J.L. (2010) Bio-informatique : principes d'utilisation des outils (Quae).

Selected invited presentations at international conferences

2012 XXIV International Congress of Entomology (Daegu, South- Korea)

2012 6th annual arthropod genomics symposium (Kansas City, USA)

2013 10th Gordon Conference “Ecology and Evolutionary Genomics” (New England, USA)

2013 Entomological Society of America’s Annual Meeting (Austin, USA)

2013 6th International Symposium on Phylloxera, (Bordeaux, France)

2014 7th International Symposium on Molecular Insect Science, (Amsterdam, Pays-Bas)

2014 4th International Conference on Diabrotica Genetics, (Chicago, USA)

2014 TGAC workshop on “regulatory elements in non-model organisms”, (Norwich, UK)

2015 2nd Global Invertebrate Genomics Alliance Workshop, (München, Allemagne)

2015 CRG (Barcelone, Espagne)

2016 International Conference on Entomolgy, (Orlando, Florica, USA)

Organization of international conferences

7th International Symposium on Molecular Insect Science Amsterdam 2014, scientific committee

IAGC (6 workshops, with the last on planned for 25th sept 2016 at Orlando, Florida, USA

Entomological Society of America’s Annual Meeting  (organization of microRNA symposium)

International Conference on Entomology (Orlando 2016) (organization of epigenetics symposium)